Ovarian rejuvenation therapy
Ovarian rejuvenation (PRP)is a procedure that can create new eggs in the ovaries of women who are unable to conceive due to early menopause, advanced maternal age or low ovarian reserve, but who wish to have their own biological child.
These individuals are able or not, for their personal reasons, to use the eggs of the donor or to adopt a child. New eggs do not develop in the ovaries under normal circumstances, and according to the current scientific understanding of ovarian physiology, a woman is born with all the eggs that will be available for conception during her reproductive life. Furthermore, it is a scientifically indisputable fact that the supply of a woman of eggs decreases in number and genetic quality as the age progresses.
How can ovarian rejuvenation happen?
The scientific basis of this clinical case of successful ovarian rejuvenation is more likely than the blood cells of patients, who were injected into the ovaries, produced substances called growth factors, which the body produces normally, in order to heal the lesions internal and external. Among the many other important biological and immunological functions, growth factors cause the growth of new blood vessels, connective and nervous tissues by the activation of stem cells that are normally found in all parts of the human body. Stem cells can, under the correct biological stimulus, transform into any type of cell in the human body, including eggs. The presence of stem cells in the ovaries and their transformation into mature oocytes (egg cells) has been demonstrated in mice by Harvard researchers. Stem cells have also been shown to be present in human ovaries, so it is quite possible that they can be transformed into eggs by growth factors contained in their own white blood cells of individuals that were injected into the ovary. Growth factor injections, when used for many other types of medical treatments, consist of the patient’s blood and blood cells and is called PRP (platelet-rich plasma) or PDGF (Platelet Derived Growth Factors).
What are the growth factors, how do they work and are they safe?
Growth factors are naturally produced by some blood cells (platelets and white blood cells) when the body is injured in order to naturally repair the body’s tissues. Remember in your childhood, “skinning” your knee and seeing a thick yellow substance form over the injured area? That was actually a combination of platelets, white blood cells, blood coagulation and growth factors that stop bleeding, prevent infection, and eventually cause new skin formation, blood vessels, connective tissues and nerves to replace those that were lost due to the injury.
PRP injections have been used clinically for many years by physicians for the treatment of soft tissue and connective tissue injuries, as well as in bone grafts. Many professional athletes use this therapy to accelerate the healing of their sports-related injuries. PRPs are also used in burned patients to help skin transplants and after cardiac surgery to aid healing of chest wall incisions.
The current clinical use of PRP is very broad, from the treatment of ulcers to non-surgical facelifts.
Of course there are research studies that both confirm and deny the effectiveness of PRP therapy in its multiple medical uses.
One thing about PRP therapy that has not been questioned is its safety. Since it is made up of a person’s blood, there can be no transmission via blood-borne viruses such as hepatitis or HIV, as has been reported with the use of other people’s blood products. Furthermore, since there are no synthetic chemicals involved and the PRP therapy is done from its own blood products of the patients; the possibility of an allergic reaction is extremely unlikely.
How is the ovarian rejuvenation procedure performed?
The process of ovarian rejuvenation involves two phases. The first is the preparation of your PRP. This begins with the insertion of a needle into the vein to obtain different tubes of blood. White blood cells and platelets are separated from red blood cells and serum by a procedure called centrifugation. Preparation of the PRP takes less than an hour. The next part of the ovarian rejuvenation process is the injection of PRP into the ovaries. The main difference in our study and the technique described in the case study is that we use a non-surgical approach for ovarian injections.
The follow-up procedure
In order to monitor whether the procedure has regenerated new eggs in the ovaries, AMH (anti-muller hormone), FSH, LH and estradiol levels are measured at monthly intervals in women who do not menstruate, and during menstrual flow in menstruating women for a period of three months.
If AMH levels increase, while FSH, LH, and estradiol levels become lower, there is evidence of objective evidence of ovarian rejuvenation.
Blood follow-up studies can be performed at our clinic or at a local blood sampling station. Participants are required to report the occurrence of spontaneous periods in menopausal women or the modification of menstrual patterns in those participants who have menstrual cycles.
Any signs or evidence that pregnancy has occurred should be reported immediately.
For those women living in remote areas or abroad, we will provide instructions and advice on follow-up, monitoring of pregnancy and care. It is important to remember that any therapeutic effect of growth factors may require 3-6 months to be observed, since any type of tissue transformation will not be immediately apparent. Although ovarian rejuvenation is observed, pregnancy may not necessarily occur, as there may be other factors that could interfere with natural conception. Furthermore, the evidence of ovarian rejuvenation occurs, the patency of the tubes should be confirmed and the male partner must be re-evaluated with a sperm test and a post-coital test. If these tests show that natural conception is unlikely, we will advise the appropriate treatment.